運動程度高與女性的氣喘控制不佳有關


  【24drs.com】一篇納入526名青少年和年輕人詢問其運動程度的研究中,研究者發現,相較於中度運動者,高度運動與女性的氣喘控制不佳有關,男性無此關聯。
  
  瑞典Uppsala大學醫學科學臨床生理學系Ludvig Lovstrom在新聞稿中表示,重點在於高度運動而非極端運動,在我們的病患資料中,有三分之一的女孩運動量就是這麼多。儘管如此,我們發現了這些結果,並且有這麼明顯的性別差異。
  
  這些線上發表於11月19日的Respirology期刊的研究結果認為,健康照護專業人士應格外注意高度運動女性的氣喘治療。
  
  診斷有氣喘、年齡10-34歲的408名病患,答覆了有關運動頻率和/或時間的問卷,也進行了氣喘控制測試、肺功能檢查、乙酰甲基膽鹼挑戰、呼出氣一氧化氮測定等,藉以測量他們的氣喘控制。
  
  對照組是118名年齡與性別配對、沒有氣喘者,隨機選自人口登記資料,這些對照組對象也回答了上述問題。
  
  根據兩部份的問卷測定運動程度,「你通常多常運動到呼吸急促或開始冒汗?(頻率)」,以及「你每週有多少小時運動到呼吸急促或開始冒汗?(時間)」
  
  我們對運動頻率和時間都定義了三種程度:頻率高(每週≧4次)、中(每週1 – 3次)與低(每個月1次或更少),以及時間高(每週≧4小時)、中(每週1 – 3小時)、和低(每週約半小時或更少) 。
  
  Lovstrom醫師等人發現,頻率中等女性的氣喘控制測試分數小於20分(未達目標)的勝算比為4.81 (95%信賴區間:2.43 - 9.51),而男性並未發現這類影響(勝算比:1.18;95%信賴區間:0.61 - 2.30)。
  
  他們也發現,在開始研究的前3個月期間,儘管有類似的局部或全身性發炎與支氣管反應,高度運動女性的氣喘發作高於中度運動的同儕。
  
  研究者表示,還不清楚是否與呼吸道直徑大小或其他觀點有關,或者只是因為氣喘女性本身的呼吸道造成較容易氣喘發作。
  
  資料來源:http://www.24drs.com/
  
  Native link:High Physical Activity Tied to Poor Asthma Control in Females
  

High Physical Activity Tied to Poor Asthma Control in Females

By Marcia Frellick
Medscape Medical News

In a study of 526 adolescents and young adults who were asked about how much they exercised, researchers found that compared with moderate physical activity, high physical activity levels were linked with poorer asthma control in females, but not males.

"It is important to remember that the high level of activity means nothing extreme — in our patient material every third girl exercised that much. Still, we uncovered these results, and with such a distinct gender difference," Ludvig Lovstrom, from the Department of Medical Sciences, Clinical Physiology, Uppsala University, Sweden said in a news release.

The findings, which were published online November 19 in Respirology, suggest that healthcare professionals should pay extra attention to the treatment of asthma in highly active females.

A group of 408 patients diagnosed with asthma, aged 10 to 34 years, answered questions concerning frequency and/or duration of physical activity and undertook the Asthma Control Test, spirometry, methacholine challenges, and exhaled nitric oxide measurements to measure their asthma control.

A group of 118 age- and sex-matched subjects who did not have asthma, randomly chosen from the population registry, served as the control group and also answered the questions.

Physical activity levels were determined from a two-part questionnaire that asked, "How often do you usually exercise so much that you get out of breath or start sweating?" (frequency) and "How many hours a week do you usually exercise so much that you get out of breath or start sweating?" (duration).

Three levels of physical activity were defined for both frequency and duration: high (?4 times a week), moderate (1 - 3 times a week) and low (once a month or less) frequency, and high-level (?4 hours a week), moderate (1 - 3 hours a week), and low (about half an hour or less each week) duration.

Dr Lovstrom and colleagues found that frequently vs moderately active females had an odds ratio of 4.81 (95% confidence interval, 2.43 - 9.51) of having an Asthma Control Test score of less than 20, whereas no such effect was found in males (odds ratio, 1.18; 95% confidence interval, 0.61 - 2.30).

They also found that highly active females experienced asthma attacks more often than their moderately active peers during the 3 months before the study, despite similar levels of local or systemic inflammation and bronchial responsiveness.

The researchers say it is unclear whether this is related to airway diameter or differing perceptions, or whether airways in females with asthma are just more predisposed to asthma attacks.

This cross-sectional study was part of a project run within the framework of an industry–academy collaboration on Minimally Invasive Diagnostics for Asthma and Allergic Diseases (MIDAS). The MIDAS study was financially supported within the framework of an academy–industry collaboration initiated by the Swedish Governmental Agency for Innovation Systems, where Aerocrine AB and Thermo Fisher Scientific Immunodiagnostics were partners and cofinanced the program. One coauthor is an employee of Thermo Fisher Scientific. No other relevant financial relationships were disclosed.

Respirology. Published online November 19, 2015.

    
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