體育補充品中的刺激物與運動誘發的中風有關


  【24drs.com】研究者表示,體育補充品中含的β-甲基苯基乙基胺(BMPEA),可能與一名大致健康的婦女在運動前使用這種補充品之後發生出血性中風有關。
  
  麻州波士頓哈佛醫學院的Pieter Cohen醫師等人指出,這篇案例報告線上發表於5月12日內科醫學誌,首度提出BMPEA這個類似安非他命的化學物質與運動誘發的中風之間的關聯。
  
  這名53歲婦女的健康狀況原本大致良好,在開始費力運動後45分鐘,突然發生左手麻木和笨拙;在最近幾年,她每週都有進行幾次相同的運動。
  
  在這名婦女進行例行運動前30分鐘,她使用了建議量(13 g)的體育補充品:Jacked Power (MM Sports公司),這是她第一次用這類體育補充品。電腦斷層顯示她的右大腦頂葉有一處2公分出血,腦部核磁共振顯示出血、無潛在異常。腦部血管攝影未發現血管炎、動脈瘤或其他血管畸形。這名婦女入院後,血壓恢復正常且維持正常,她在5天後出院,有輕微的殘留感覺症狀。
  
  這篇案例最初發表於2014年9月的瑞典醫學期刊L kartidningen (2014;111:1782-1784)。
  
  這篇最初報告之後,分析這名婦女使用的Jacked Power補充品,發現每一劑量含有290 mg的BMPEA。
  
  Cohen醫師等人結論指出,運動時使用BMPEA可能引起這個患者的中風。
  
  BMPEA是唯一未被標示的藥品,BMPEA或草本的金合歡(Acacia rigidula)都沒有被列於補充品標籤。美國食品藥物管理局(FDA)在2013年進行的研究確認BMPEA不是A. rigidula的成分或萃取物。
  
  Cohen醫師等人在他們的文章中指出,BMPEA是一種合成化合物,對人類的健康影響未知,它會增加貓狗的血壓與心律,在市售的十多種減重與改善運動員表現的補充品中都有發現含有BMPEA。
  
  上個月,FDA提醒多家公司停止販售含有BMPEA與另一種刺激物1,3-二甲基丁胺(1,3-dimethylbutylamine [DMBA])的補充品。BMPEA和DMBA都類似於FDA已經禁用的1,3-二甲基戊基胺(1,3-dimethylamylamine [DMAA])。
  
  Cohen醫師在聲明中表示,飲食補充品可以合法販售用來改善運動,即便並無證據證明它們真的對人類有用。這變相鼓勵一些廠商將未經檢驗的藥物導入體育補充品,用來達到宣傳的效果。可悲的是,未經檢驗的刺激物對不知情的消費者可能會有嚴重的健康風險。
  
  研究者鼓勵美國醫師報告在www.safetyreporting.hhs.gov向FDA通報所有疑似飲食補充品導致的嚴重不良反應。至於歐洲,他們建議醫師應對適當的國家管理當局報告這些事件。
  
  MM Sports公司的Andreas Karlsson被要求對些結果提出反應 。
  
  Karlsson指出,在9個月前,我們還沒聽過這類報告時已將這個產品下架,這個產品已經停止銷售將近一年半。當時自動下架是因為銷售因素,不是因為有任何安全考量。
  
  Karlsson指出,苯乙胺(Phenethylamines [PEAs])已經在歐盟與美國市場使用超過10年,就我們所知,沒有任何負面報告。
  
  資料來源:http://www.24drs.com/
  
  Native link:Stimulant in Sports Supplement Linked to Exercise-Induced Stroke

Stimulant in Sports Supplement Linked to Exercise-Induced Stroke

By Megan Brooks
Medscape Medical News

β-Methylphenylethylamine (BMPEA) found in a sports supplement is likely to blame for hemorrhagic stroke in an otherwise healthy women who took the supplement before exercising, investigators say.

The case report, published online May 12 in Annals of Internal Medicine, is the first to suggest a connection between BMPEA, a chemical relative of amphetamine, and exercise-induced stroke, note Pieter Cohen, MD, from Harvard Medical School, Boston, Massachusetts, and colleagues.

The 53-year-old woman, who was previously healthy and in good physical condition, experienced sudden onset of numbness and clumsiness in her left hand about 45 minutes after starting a vigorous workout — the same workout she had repeated several times a week for a few years.

Thirty minutes before she started her regular workout, the woman reported consuming the recommended dose (13 g) of the sports supplement Jacked Power (MM Sports). It was the first time she had consumed this or any similar sports supplement.

Computed tomography of the head showed a 2-cm hemorrhage in the right parietal lobe. MRI of the brain revealed the hemorrhage, with no underlying abnormalities. Cerebral angiography showed no evidence of vasculitis, aneurysm, or other vascular malformation. Blood pressure normalized after the woman was admitted to the hospital, and it remained normal. She was discharged after 5 days with minor residual sensory symptoms.

BMPEA Likely Culprit?

The case was first reported in September 2014 in the Swedish medical journal Lakartidningen (2014;111:1782-1784).

After this initial report, the Jacked Power supplement the woman consumed was analyzed and found to contain 290 mg of BMPEA per dose.

"Exercise combined with BMPEA probably caused this patient's stroke," Dr Cohen and colleagues conclude.

BMPEA was the only unlabeled pharmaceutical or drug found. Neither BMPEA nor the botanical Acacia rigidula was listed on the supplement label. Research conducted by the US Food and Drug Administration (FDA) in 2013 established that BMPEA is not a constituent or extract of A rigidula.

Dr Cohen and colleagues note in their article that BMPEA is a synthetic compound with unknown health effects in humans. It raises blood pressure and heart rate in dogs and cats. BMPEA has been found in more than a dozen brands of supplements marketed to promote weight loss and improve athletic performance.

Last month, the FDA warned several companies to stop selling dietary supplements containing BMPEA and another stimulant, 1,3-dimethylbutylamine (DMBA). BMPEA and DMBA are similar to 1,3-dimethylamylamine (DMAA), which has already been banned by the FDA.

"Dietary supplements can legally be sold to improve workouts even when there is zero evidence that they actually work in humans," Dr Cohen said in a statement. "This creates a perverse incentive for manufacturers to introduce untested drugs into sports supplements to achieve the advertised effect. Tragically, untested stimulants can pose serious health risks to unsuspecting consumers."

The researchers encourage physicians in the United States to report all suspected serious adverse events from dietary supplements to the FDA at www.safetyreporting.hhs.gov. In Europe, physicians should report these events to the appropriate national authority, they advise.

Asked to respond to these findings, Andreas Karlsson from MM Sports told

Karlsson added, "We removed the product from sales over 9 months before we ever heard about the report or anything thereof — and the product hasn't been out for sale for nearly a year and a half. The removal of the product was voluntary due to marketing reasons and not because of any safety regards.

"Phenethylamines (PEAs) have been around for over 10 years in the EU [European Union] and US markets, without any negative reports to our knowledge," Karlsson noted.

The authors have disclosed no relevant financial relationships.

Ann Intern Med. Published online May 6, 2015.

    
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