長期濫用處方止痛藥比率激增


【24drs.com】新報告發現,自2002年來,美國定期使用處方止痛藥如oxycodone且非醫療原因者激增,這些藥物的致命過量案例也是。
  
  疾病管制中心(CDC)、國家傷害預防與控制中心Christopher M. Jones博士表示,伴隨著鴉片類止痛藥的發病率和死亡率增加,這些研究結果強調,需要協調一致的公共衛生和公共安全行動,以防止非醫療原因使用這些藥物。
  
  他結論表示,介入方式應聚焦在慢性非醫療原因使用的風險最大者:18-49歲男性。
  
  該報告線上登載於6月25日內科醫學誌。
  
  Jones醫師合併了2002–2003年和2009–2010年的「美國全國藥物濫用及健康調查」資料,分析因為非醫療原因使用處方止痛藥的頻率與趨勢。他發現,長期(過去一年使用200天以上)非醫療原因使用處方止痛藥的比率,從每1000人2.2 - 3.8增加到74.6% (P < .01)。
  
  Jones醫師表示,這是重要結果,因為最近幾年同樣增加的還有過量致死案例、住院治療、和鴉片類止痛藥有關的其他負面影響。
  
  例如,CDC的2011年11月版報告發現,美國鴉片類處方止痛藥的過量死亡案例數已經達到流行病學的程度,超過海洛因和古柯鹼的死亡數總和。
  
  Jones醫師分析發現,男性的長期非醫療原因使用處方止痛藥增加幅度最大(增加105%),依年齡分析則是26-34歲者(81%)與35-49歲者(135%)。
  
  他指出,令人鼓舞的發現是,12-17歲者之非醫療原因使用處方止痛藥物的比率逐年降低。然而,令人擔心的是,2009–2010年的調查中,近0.4%的12-17歲者(約100萬人)表示因為非醫療原因使用止痛藥達200天以上,約2%(相當於460萬人)使用30天以上。
  
  藥物濫用與精神衛生服務局(SAMHSA)的2010年研究發現,12歲以上因濫用處方止痛藥的住院比率,在10年間(1998–2008)增加達400%。
  
  資料來源:http://www.24drs.com/professional/list/content.asp?x_idno=6866&x_classno=0&x_chkdelpoint=Y
  

Chronic Abuse of Prescription Pain Meds Up Sharply

By Megan Brooks
Medscape Medical News

June 26, 2012 – The number of Americans who regularly use prescription pain relievers such as oxycodone for nonmedical reasons has shot up since 2002, in parallel with fatal overdoses of these drugs, a new report finds.

"Coupled with continued increases in opioid pain reliever morbidity and mortality, these findings underscore the need for concerted public health and public safety action to prevent nonmedical use of these drugs," says the author of the report, Christopher M. Jones, PharmD, MPH, from the National Center for Injury Prevention and Control, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.

"Interventions should focus on populations at greatest risk for chronic nonmedical use: men and persons aged 18 to 49 years," he concludes.

The report was published online June 25 in Archives of Internal Medicine.

Dr. Jones combined data from the National Survey on Drug Use and Health for the years 2002–2003 and 2009–2010 to analyze trends in the frequency of the nonmedical use of prescription pain relievers.

He found that the rate of chronic nonmedical use of prescription pain relievers — 200 days or more in the past year — increased from 2.2 to 3.8 per 1000 people, an increase of 74.6% (P < .01).

"This finding is important because it parallels increases in overdose deaths, treatment admissions, and other negative effects associated with opioid pain relievers in recent years," Dr. Jones says.

For example, as reported by Medscape Medical News, a November 2011 report from the CDC found that the number of overdose deaths from opioid prescription pain relievers in the United States has reached epidemic proportions and is now greater than fatalities from heroin and cocaine combined.

In his analysis, Dr. Jones found that some of the largest increases in chronic nonmedical use of prescription pain medications occurred among men (105% increase) and adults aged 26 to 34 years (81%) and 35 to 49 years (135%).

One "encouraging finding," he says, is the decrease in any past-year nonmedical use of prescription pain medications in persons in the 12- to 17-year-old age range.

Nonetheless, he says it is "concerning" that nearly 0.4% of people aged 12 to 17 years — which is almost 1 million people — reported using pain relievers for nonmedical reasons for 200 days or more in 2009–2010, and that roughly 2% — or 4.6 million people — used them for 30 days or more.

As previously reported by Medscape Medical News, a 2010 study by the Substance Abuse and Mental Health Services Administration (SAMHSA) found that hospital admissions due to substance abuse increased by 400% during a 10-year period (1998–2008) among people older than 12 years as a result of misuse of prescription pain relievers.

Dr. Jones has disclosed no relevant financial relationships.

Arch Intern Med. Published online June 25, 2012.

    
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