IBS患者的GERD盛行率高達4倍


  【24drs.com】根據英國Leeds胃腸科研究院Rebecca M. Lovell醫師在2012消化道疾病週發表的統合分析,大腸激躁症(IBS)患者的胃食道逆流症(GERD)盛行率是沒有IBS者的4倍。
  
  IBS和GERD都是一般人常見的疾病,兩者之間被認為有某種程度的相似處,但這個關聯尚未被整體檢視,研究者因而進行了系統回顧與統合分析,以確認IBS患者的GERD盛行率。
  
  回顧文獻共檢索評估390篇研究,有80篇人口基礎研究依據各種可接受的規範提及IBS盛行率,其中13篇研究、49,939名研究對象提到同一族群內有部分人符合GERD準則。
  
  Lovell醫師報告指出,這13篇研究彙整的IBS盛行率為11.6% (95%信心區間[CI]7.1%-17.1%),與沒有IBS者相比,IBS者的GERD達4.17倍 (95% CI,2.85- 6.09)。
  
  有趣的是,IBS者同時患有GERD的機率則是因IBS的定義而異。
  
  IBS患者同時有GERD之機率
準則 研究篇數 人數 勝算比
Manning 3 5708 3.83
Rome I 5 6580 3.53
Rome II 3 18,470 4.63
Rome III 1 18,180 3.44
問卷 1 1001 9.59
任何方式 13 49,939 4.17

  她指出,交集的程度因所用的IBS定義而異,但是皆顯著,這個關聯強度認為有共通的發病機轉。
  
  資料來源:http://www.24drs.com/professional/list/content.asp?x_idno=6827&x_classno=0&x_chkdelpoint=Y
  

Prevalence of GERD is 4 Times Higher Among People With IBS

By Caroline Helwick
Medscape Medical News

May 19, 2012 (San Diego, California) — The prevalence of gastroesophageal reflux disease (GERD) is 4 times greater in people with irritable bowel syndrome (IBS) than in those without IBS, according to a meta-analysis presented by Rebecca M. Lovell, MD, from Leeds Gastroenterology Institute in the United Kingdom, here at Digestive Disease Week 2012.

IBS and GERD are both common disorders in the general population. Although it is thought that there is a degree of overlap between the 2, the strength of this association has not been examined systematically. The investigators, therefore, performed a systematic review and meta-analysis to estimate the prevalence of GERD in people with IBS.

With a literature review, 390 studies were retrieved for assessment. There were 80 separate population-based studies that reported the prevalence of IBS, according to various accepted criteria. Of these, 13 studies, with 49,939 participants, reported the proportion of people who met the criteria for GERD within the same population.

The pooled prevalence of IBS in these 13 studies was found to be 11.6% (95% confidence interval [CI], 7.1% to 17.1%). The odds of GERD in people with IBS, compared with those without, was 4.17 (95% CI, 2.85 to 6.09), Dr. Lovell reported.

Interestingly, the odds of an individual with IBS also having GERD varied according to the criteria used to define IBS.

Odds of a Person With IBS Also Having GERD
Criteria Studies, n Population, n Odds Ratio
Manning 3 5708 3.83
Rome I 5 6580 3.53
Rome II 3 18,470 4.63
Rome III 1 18,180 3.44
Questionnaire 1 1001 9.59
Any 13 49,939 4.17


"The degree of overlap varied according to the criteria used to define IBS, but remained significant in all cases," she noted. "The strength of this association suggests common pathogenetic mechanisms."

Dr. Lovell has disclosed no relevant financial relationships.

Digestive Disease Week (DDW) 2012. Abstract 7. Presented May 19, 2012.

    
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