擴大使用羥丁醛對兒童進行治療是安全有效的

比傳統的使用模式更容易獲得患者的配合

  2002年3月26日報導──據《Urology》雜誌3月份一期中報導的,一項關於25名兒童的回顧性研究的結果顯示,擴大使用羥丁醛對治療尿失禁的兒童和成年人是安全有效的。

  紐約Albany醫科大學的Katrin Youdim和Barry A. Kogan寫道:「由於羥丁醛的副作用,其在兒童中使用的效率受到限制,一種新的擴大化使用羥丁醛的方法,可以獲得傳統羥丁醛使用方法所不能獲得的好處,但是這還沒在兒童中進行效果的評估。」

  在擴大的羥丁醛治療後,所有的25名患者出現尿失禁症狀的緩解或避免了功能的喪失。這些患者包括14名患有神經性膀胱功能失調的患者,和11名沒有神經性損傷,但出現尿頻,尿急和尿失禁的患者。

  其中有13名兒童(52%)報告產生副作用。10人被報告出有口乾,4人被報告出有便秘,4人被報告出對熱不耐受,和3人被報告有嗜睡現象。曾經接受過羥丁醛治療的患者報告,擴大化的羥丁醛治療同樣有效或更有效,其副作用與以前的治療相比,兩者是相似的或後者要少,尤其口乾的現象變少了。

  家庭研究的報告顯示,擴大化羥丁醛治療比傳統的羥丁醛治療更容易得到患者的配合。患者和家庭的滿意程度很高,25名患者中的21人繼續接受這種治療。

  作者寫道:「擴大化羥丁醛治療對兒童患者來說是安全有效的。在這次預試驗中,它比傳統的、短期的使用羥丁醛治療的效果要好。」

Extended-Release Oxybutynin Safe, Effective in Children

Better Compliance Than With Traditional-Release Form

By Laurie Barclay, MD
WebMD Medical News

Reviewed by Gary D. Vogin, MD

March 26, 2002 -- Extended-release oxybutynin is safe and effective in treating incontinence in children as well as in adults, based on a retrospective study of 25 children in the March issue of Urology.

"The efficacy of oxybutynin in children has been limited by side effects," write Katrin Youdim and Barry A. Kogan from Albany Medical College in New York. "A new extended-release formulation of oxybutynin has some benefits versus traditional oxybutynin but has never been evaluated in children."

All 25 patients had improvement in incontinence and/or voiding dysfunction on extended-release oxybutynin. These included 14 with neurogenic bladder dysfunction and 11 with urinary frequency and urgency and urge incontinence without neurologic abnormalities.

Of the 13 children (52%) who reported side effects, 10 complained of dry mouth, four had constipation, four had heat intolerance, and three had drowsiness. Patients previously treated with oxybutynin reported that the extended-release oxybutynin was equally or more effective and had the same or fewer side effects, especially less dry mouth.

Families reported much better patient compliance with extended-release oxybutynin than with traditional oxybutynin. Patient and family satisfaction was very high, and 21 of 25 continued using the medication.

"Extended-release oxybutynin is safe and efficacious in children," the authors write. "In this preliminary evaluation, it had benefits over traditional, immediate-release oxybutynin."

© 2002 WebMD Inc. All rights reserved.

    
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