肥胖和癌症之間的關聯備受矚目


  【24drs.com】目前一篇探討肥胖與癌症關聯的研究中,國家癌症研究中心(NCI)付款項給「能量學與癌症之跨科別研究(Transdisciplinary Research on Energetics and Cancer,TREC)」這項計畫主題,這個總值4500萬美元、為期5年的計劃也將研究預防肥胖的方法,特別是對於孩童與癌症存活者。
  
  這篇計畫的研究目標涵蓋肥胖的生物與生理機轉,行為、社會文化及環境對營養、運動和體重的影響。根據即將成為TREC之協同中心的Fred Hutchinson癌症研究中心聲明稿,所有研究的潛在主題在於致力瞭解能量學(轉變時的能量)和癌症之間的關聯。
  
  NCI所屬癌症控制與人口科學小組Robert Croyle博士在聲明稿中表示,NCI相當關注肥胖流行病學與其對癌症的影響,這項投資反映出問題的急迫性,以及加速研究癌症控制策略的需求。
  
  在多篇研究中,肥胖和發生或死於多種癌症的風險有密切關聯,例如乳癌、結腸癌、食道癌。美國癌症協會指出,估計約有30%的癌症死亡是因為營養不佳、過重與缺乏運動。
  
  NCI在2005年開始TREC計劃,最初資金為5,400萬美元,其中530萬美元撥給Hutchinson中心建立協同中心。
  
  TREC研究將在Hutchinson中心、哈佛大學、加州大學聖地牙哥分校、賓州大學以及華盛頓大學等四地進行。
  
  這篇研究的特色之一就是合作性的跨科別研究。Hutchinson中心公衛科學小組的Mark Thornquist博士在聲明稿中表示, TREC的觀念在於由跨領域的研究者探究肥胖和癌症的關聯,參與的有營養科學、分子流行病學與行為科學等科別;Thornquist博士將擔任該計畫之協同中心的主要研究員。
  
  他進一步解釋,藉由從許多面向探討問題與整合研究,我們希望可以比那些小範圍研究有更快速的科學進展。
  
  根據UCSD家庭與預防醫學科教授、Moores癌症中心癌症預防與控制計畫組長Ruth Patterson 博士,研究之一將探討胰島素阻抗性,以及能量平衡與乳癌之關聯的相關資訊。
  
  她指出,研究目標在揭開肥胖與乳癌風險的關聯,如果我們瞭解肥胖和風險之間的生物機轉,那麼我們就可能據以設計生活型態介入方式,或檢視哪些藥物可降低風險。
  
  資料來源:http://www.24drs.com/professional/list/content.asp?x_idno=6585&x_classno=0&x_chkdelpoint=Y
  

Link Between Obesity and Cancer Under Scrutiny

By Nick Mulcahy
Medscape Medical News

July 29, 2011– In an ongoing effort to better understand the link between obesity and cancer, the National Cancer Institute (NCI) has refunded the initiative known as the Transdisciplinary Research on Energetics and Cancer (TREC).

The $45 million, 5-year program also will study ways to prevent obesity, particularly among children and cancer survivors.

The initiative's research projects range from the biologic and physiologic mechanisms of obesity to the behavioral, sociocultural, and environmental influences on nutrition, physical activity, and weight. The underlying theme of all the research is the effort to understand the relation between energetics (energy under transformation) and cancer, according to a press statement from the Fred Hutchinson Cancer Research Center in Seattle, Washington, which will act as TREC's coordinating center.

"NCI is very concerned about the epidemic of obesity and its implications for cancer," said Robert Croyle, PhD, director of NCI's division of cancer control and population sciences, in a press statement. "This investment reflects the urgency of the problem and the need to accelerate scientific progress to inform cancer-control strategies."

Obesity has been tied to the risk of either developing or dying from a variety of cancers, such as those of the breast, colon, and esophagus, in multiple studies, as reported by Medscape Medical News. The American Cancer Society has reportedly estimated that about 30% of cancer deaths are due to poor nutrition, excess weight, and lack of exercise.

The NCI launched the TREC initiative in 2005 with $54 million in initial funding, $5.3 million of which went to the Hutchinson Center to establish the coordinating hub.

TREC research will take place at 4 institutions in addition to the Hutchinson Center: Harvard University in Boston, Massachusetts; University of California San Diego (UCSD); University of Pennsylvania in Philadelphia; and Washington University in St. Louis, Missouri.

One of the hallmarks of the study is cooperative, multidisciplinary research. "The idea behind TREC was to attack the problem of obesity and cancer with teams of researchers from many scientific fields, such as nutrition science, molecular epidemiology, and behavioral science," said Mark Thornquist, PhD, from the Hutchinson Center's public health sciences division, in a press statement. Dr. Thornquist will act as principal investigator of the initiative's coordinating center.

"By approaching the problem from many directions and collaborating across studies, we hope to make scientific progress faster than more narrowly focused research," he further explained.

One of the studies will look at insulin resistance and inflammation underlying the relation between energy balance and breast cancer, according to Ruth Patterson, PhD, a professor in the UCSD Department of Family and Preventive Medicine, and program leader of the cancer prevention and control program at Moores Cancer Center at the university.

"Our study aims to uncover the mechanistic links between obesity and breast cancer risk. If we understand the biological mechanisms linking obesity with risk, then we have the potential to design lifestyle interventions or identify drugs to reduce disease risk," she said in a press statement.

    
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