BMD與停經後婦女的口乾有關


  【24drs.com】根據一項新研究,骨質密度(BMD)與停經後婦女較不會感到口乾有關。
  
  來自伊朗德黑蘭大學醫學院牙醫學院口腔醫學/牙科研究部門的Farzaneh Agha-Hosseini牙科博士與同事們將他們的研究結果線上發表在更年期(Menopause)期刊上。
  
  作者們解釋,雌性激素、副甲狀腺荷爾蒙、以及皮質荷爾蒙都與骨質更迭有關;此外,最近的證據顯示,口乾患者的雌性激素顯著較低、副甲狀腺荷爾蒙與皮質醇濃度顯著較高。
  
  為了進一步研究這之間的關係,研究人員進行了一項斷面性研究,收納60位挑選出的停經後婦女,這些患者年齡介於45到79歲,其中30位有口乾的問題,以口乾症評分量表測量,另外30位沒有口乾的問題。
  
  報告口乾的停經後婦女,未受刺激的唾液流量顯著比沒有口乾的女性低(0.26 mL/min ± 0.01 比上0.33 mL/min ± 0.01;P < .05)。
  
  他們也發現,相較於控制組女性,有口乾的婦女平均腰椎BMD顯著較低(P<.01),且停經後婦女的口乾評分量表分數與BMD之間有顯著負向關係(r = -0.334;P < .05),代表口乾嚴重度與BMD下降有關。
  
  這項研究的一個限制是,因為斷面性研究設計限制,無法確認BMD與口乾之間時序上的關係;如果要研究因果關係,需要縱面性研究設計。
  
  Agha-Hosseini牙科博士與同事們的結論是,就我們所知,這是第一項評估有口乾感受停經後婦女的腰椎BMD研究。他們建議,這些研究數據應該在之後的大型研究中,引入口乾感作為骨質疏鬆症的一個併發症。
  
  他們附帶表示,許多婦女造訪牙科的機會高於內科門診,因此,牙醫師對於骨質疏鬆症的知識應可以提供比目前更早的代謝骨疾病診斷。
  
  資料來源:http://www.24drs.com/professional/list/content.asp?x_idno=6482&x_classno=0&x_chkdelpoint=Y
  

BMD Associated With Oral Dryness in Postmenopausal Women

By Emma Hitt, PhD
Medscape Medical News

March 17, 2011 — Bone mineral density (BMD) appears to be significantly lower in postmenopausal women experiencing oral dryness, according to new research.

Farzaneh Agha-Hosseini, DDS, MSc, from the Department of Oral Medicine/Dental Research Center, School of Dentistry, at the Tehran University of Medical Science in Iran, and colleagues reported the findings online February 19 in Menopause.

Estrogen, parathyroid hormone, and cortisol hormones are all associated with bone turnover; in addition, recent evidence suggests that estrogen is significantly lower and parathyroid hormone and cortisol higher in women with oral dryness, the authors explain.

To investigate this association further, the researchers conducted a cross-sectional study of 60 selected postmenopausal women aged 45 to 79 years, 30 of whom experienced oral dryness, as measured by the xerostomia inventory score, and 30 of whom did not.

Unstimulated salivary flow rate was significantly lower in postmenopausal women reporting oral dryness compared with women not reporting oral dryness (0.26 mL/min ± 0.01 vs 0.33 mL/min ± 0.01; P < .05).

They also found that the mean lumbar spine BMD was significantly lower in postmenopausal women reporting oral dryness than in control women (P < .01), and there was a significant negative correlation between xerostomia inventory score and BMD in postmenopausal women (r = ?0.334; P < .05), indicating that oral dryness severity was associated with decreasing BMD.

One limitation of the study is the inability to determine temporal relationship between BMD and oral dryness because of the cross-sectional design; to comment on cause and effect, a longitudinal design is needed.

"To the best of our knowledge, this is the first study to assess lumbar spine BMD in postmenopausal women with [oral dryness] feeling," Dr. Agha-Hosseini and colleagues conclude. "These data should be followed by a larger study to introduce [oral dryness] feeling as a complication of osteoporosis," they suggest.

They add that many women visit a dental office more often than a medical office, and therefore, "dentists' knowledge about manifestation of osteoporosis could provide an earlier diagnosis of metabolic bone diseases than is currently available."

The study was supported by the Dental Research Center, School of Dentistry, Tehran University of Medical Sciences. The authors have disclosed no relevant financial relationships.

Menopause. Published online February 19, 2011.

    
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