蜂蠟可改善與輕度子宮內膜異位相關的不孕症


  Oct. 17 ,2003--根據一項小型隨機試驗的研究發現,蜂蠟可有效治療與輕度子宮內膜異位有關的不孕症,「蜂蠟」是蜜蜂所收集的植物樹脂,根據埃及開羅Ain Shams大學的Ali F. M. Al及其同事表示,這種物質有「許多藥理學的作用」,包括C aromatase的抑制及血管內皮生長因子及強大的抗發炎活動。
  
  醫生Ali和同事在這星期於德州聖安東尼奧所舉辦的美國生殖醫學協會第59屆的年度會議上發表他們的研究發現。
  
  研究人員引導了一項含有至少兩年未懷孕過且經腹腔鏡檢查診斷為子宮內膜異位的40位病患的研究,病患被隨機分配到接受每天兩次的500mg蜂蠟或是安慰劑並追蹤九個月。
  
  在接受蜂蠟的病患中有12位女性(60%)懷孕,比較之下,安慰劑組則有4位(20%) (<.001),作者在摘要中提到,病患的反應是令人滿意且沒有任何副作用。
  
  研究人員總結表示,蜂蠟對於與輕度或及輕微的子宮內膜異位相關的不孕症是一個有效的治療方法,他們同時指出這項調查雖然是一項病患有限的試驗性研究,但是結果卻可以預見未來有關蜂蠟的多中心、前瞻性的試驗將會被核准。

Bee Propolis May Improve Infer

By Emma Hitt, PhD
Medscape Medical News

Oct. 17, 2003 — Bee propolis appears to be effective for the treatment of infertility associated with mild endometriosis, according to the findings of a small randomized trial.

Propolis is derived from plant resins collected by honeybees. According to Ali F. M. Ali, from the Ain Shams University, in Cairo, Egypt, and colleagues, the substance has "many pharmacologic actions," including inhibition of C aromatase and vascular endothelial growth factor as well as strong anti-inflammatory activity.

Dr. Ali and colleagues presented their findings this week at the 59th annual meeting of the American Society of Reproductive Medicine in San Antonio, Texas.

The researchers conducted a study of 40 patients with primary infertility for at least two years and endometriosis diagnosed with laparoscopy. Patients were randomized to receive 500 mg of bee propolis twice daily or a placebo and were followed for nine months.

Of the patients taking bee propolis, 12 women (60%) became pregnant compared with four (20%) in the placebo group (P < .001).

"The compliance of patients was satisfactory with no reported side effects," the authors note in their abstract.

The researchers conclude that "bee propolis is an effective line of treatment for infertility associated with mild or minimal endometriosis."

They point out that their research was a pilot study with a limited number of patients, but that the results indicate that a "multicenter prospective trial of bee propolis is warranted."

ASRM 2003 Annual Meeting: Abstract O-84. Presented Oct. 13, 2003.

Reviewed by Gary D. Vogin, MD

    
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