Jan. 21, 2003 - 一月份Archives of Dermatology 的一項研究報告指出,Botox成功治療腋下多汗,建議狐臭可用相似的方法來治療。
  德國慕尼黑Ludwig-Maximilian大學的皮膚科專家Marc Heckmann博士與其同僚表示,肉毒桿菌毒素A可以培育令人愉快的香味物質,或許可以重新平衡汗腺的分泌方式,預防不愉快微生物降解產生的異味。
  這項隨機雙盲的研究中,為16名健康志願者一側腋下 (平均年齡27歲) 注射100 U 肉毒桿菌毒素A,另一側腋下注射0.9%氯化鈉。從開始至治療後七天,評估汗臭味的等級。汗臭程度:零代表沒有味道,六代表汗臭最嚴重,情緒方面:-3是最難以接受的味道,+3是最令人愉快的味道。
  治療前平均汗臭程度是2.69,氯化鈉注射七天後是2.9,肉毒桿菌毒素A注射後七天是1.83 (P = .02)。受試者報告指出,注射肉毒桿菌毒素後腋下明顯變得比較乾燥,與對照組相較汗臭減少 (mean rating, 0.46 vs. -1.14; P = .01)。

Botox May Reduce Body Odor

By Laurie Barclay, MD
Medscape Medical News

Jan. 21, 2003 — Botox successfully treats axillary hyperhidrosis, and a new study reported in the January issue of the Archives of Dermatology suggests that bromhidrosis may be similarly treatable.

"Botulinum toxin A may foster favorable odorous substances by rebalancing apocrine and apoeccrine secretion patterns and/or preventing unpleasant smells of microbial degradation," write Marc Heckmann, MD, from Ludwig-Maximilian-University in Munich, Germany, and colleagues.

In this randomized, double-blinded study, 16 healthy subjects (average age, 27 years) were injected with 100 U botulinum toxin A in one axilla and with 0.9% sodium chloride solution in the other axilla. At baseline and at seven days after treatment, subjects assessed their own body odor and that of the other subjects by sniffing patches cut from the armpit sections of T-shirts worn for 24 hours. They rated odor intensity from 0 for no odor to 6 for the most intense odor, and emotional valence of the odor from -3 for most unpleasant to +3 for most pleasant.

Mean rating for intensity of body odor was 2.69 before treatment, 2.9 seven days after sodium chloride injection, and 1.83 seven days after botulinum toxin A injection (P = .02). Subjects also reported that the botulinum toxin A-injected axilla was markedly dry compared with the control axilla. Odors of the botulinum toxin A-treated axillae were rated as being more pleasant than those emanating from the control axillae (mean rating, 0.46 vs. -1.14; P = .01).

"Axillary injection of botulinum toxin A can significantly ameliorate the intensity and improve the quality of body odor," the authors write. "The underlying mechanisms may include interference with skin microbes and denervation of apoeccrine sweat glands, but this remains to be further investigated."

Arch Dermatol. 2003;139(1):57-59

Reviewed by Gary D. Vogin, MD

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