洗桑拿浴與失智、阿茲海默氏症風險降低有關


  【24drs.com】新研究認為,定期洗桑拿浴放鬆與失智及阿茲海默氏症(AD)風險降低有關—至少在男性是如此。
  
  在芬蘭納入超過2,300名、於研究開始時被認為是健康之中年男性「Kuopio Ischemic Heart Disease (KIHD)」研究的進一步結果顯示,追蹤20年時,每週洗桑拿浴4-7次的男性,發生失智的機率比每週使用桑拿1次者降低66%。此外,他們的AD風險也降低了65%。
  
  研究者寫道,這篇報告是第一個提供了有希望之結果的前瞻研究,顯示桑拿浴是常見之記憶疾病的潛在保護生活方式因素,並指出,這項實務可能是一個可推薦的介入方式,以預防健康成年人的前述狀況。
  
  不過,他們指出,需要在女性等其他病患族群進行更多研究。
  
  資深作者、東芬蘭大學教授Jari Antero Laukkanen博士表示,他對結果很滿意。
  
  Laukkanen醫師表示,這項研究令人驚訝,因為研究結果是如此強烈。人們對桑拿浴有正面的感覺,這可能有助於部分解釋所發現的關聯。
  
  這些結果線上發表於12月7日年齡和老化期刊。
  
  研究者先前檢視了KIHD研究對象,以確認桑拿浴和心血管事件之間的可能關聯。
  
  他們發現,相較於每週只有1次桑拿浴的男性,每週使用桑拿浴2、3次的男性,18年後心因性猝死/致命的冠狀動脈心臟病、致命的心血管疾病、所有原因死亡率顯著降低。
  
  當時,加州大學舊金山分校的Rita F. Redberg醫師在JAMA內科醫學期刊撰寫編輯附註時指出,雖然這項研究並沒有檢視機轉,但是顯然確實有花時間在桑拿浴。
  
  Laukkanen醫師指出,探討與心血管疾病的關聯之後,研究者將注意力轉向失智,因為,整體而言,它們通常擁有共病症與風險因素。
  
  原本的KIHD研究是為了檢視動脈粥狀硬化心血管結果的風險因素,研究對象是東芬蘭的隨機取樣男性人口。
  
  為了此次的分析,研究者檢視了表示有使用桑拿浴的2,315名研究對象,全部都是男性、開始時的年齡為42-60歲(平均年齡53.1歲)。
  
  所有研究對象都是使用傳統的芬蘭桑拿,溫度80-100°C的乾燥氣浴,濕氣是透過將水灑在桑拿加熱器的熱岩石上而暫時地增加。
  
  根據每週使用桑拿的平均次數將這些男性分成3小組:每週1次(n = 601)、每週2-3次(n = 1513)、每週4-5次(n = 200)。
  
  平均追蹤時間是20.7年,就每組而言,從使用桑拿次數最少到次數最多者,失智診斷的百分比分別是10%、9%與4%;AD診斷百分比分別是6%、6%與3%。
  
  校正年齡、身體質量指數、抽菸、飲酒、曾發生心肌梗塞等因素之後,相較於每週1次桑拿浴者,每週4-5次桑拿浴者的失智風險比(HR)是0.34(95%信賴區間[CI], 0.16 - 0.71; P = .004);而AD的HR則是0.35 (95% CI, 0.14 - 0.90; P = .03)。
  
  相較於每週1次桑拿浴者,每週2-3次桑拿浴者與失智或AD並無顯著關聯。
  
  研究者寫道,整體而言,研究結果顯示,桑拿浴頻率與失智及AD風險之間有強力的反比關係,且與已知的風險因素無關。
  
  最近的證據認為,發炎和氧化壓力可能是促成失智的病因。
  
  研究者寫道,因此,我們的結果生物學上是可行的,因為定期桑拿浴與改善血管內皮功能有關,且可減少發炎情況。
  
  另外,桑拿浴可能有益於降低全身高血壓和升高的脈搏壓,這些都是失智的已知風險因素。
  
  Laukkanen醫師指出,他認為結果可推廣到北半球的其他人口:氣候寒冷的北歐和北美國家,但是我不知道推廣到溫暖氣候國家的情況會是怎樣。
  
  他報告指出,研究者正在計畫後續研究,將探討女性的此一關聯以及和使用桑拿有關的其他生理變化。
  
  資料來源:http://www.24drs.com/
  
  Native link:Sauna Use Linked to Lower Dementia, Alzheimer's Risk

Sauna Use Linked to Lower Dementia, Alzheimer's Risk

By Deborah Brauser
Medscape Medical News

Partaking regularly in the relaxing practice of sauna bathing is associated with a decreased risk for dementia and Alzheimer's disease (AD) — at least in men, new research suggests.

Further results from the Kuopio Ischemic Heart Disease (KIHD) study, which included more than 2300 middle-aged men in Finland who were deemed healthy at baseline, showed that those whose sauna use averaged 4 to 7 times per week were 66% less likely to develop dementia at 20-year follow-up than men who used a sauna once a week. In addition, they had a 65% risk reduction for AD.

The report "provides promising results from the first prospective study that shows sauna bathing to be a potential protective lifestyle factor for common memory diseases," write the investigators, adding that the practice "may be a recommendable intervention" to prevent the condition in healthy adults.

However, they note that more studies are needed in different patient populations, including women.

Still, senior author Jari Antero Laukkanen, MD, PhD, professor at the University of Eastern Finland, Kuopio, told Medscape Medical News that he was pleased with the results.

"This study was surprising because the findings were so strong," said Dr Laukkanen. "People have positive feelings about sauna bathing," which may help in part to explain the associations found, he added.

The results were published online December 7 in Age and Ageing.

"Time Well Spent"

As reported by heartwire from Medscape, the investigators previously examined the KIHD study population to determine possible links between sauna bathing and cardiovascular events.

They found that the men who used saunas as little as two to three times per week had significantly lower rates of sudden cardiac death/fatal coronary heart disease, fatal cardiovascular disease, and all-cause mortality 18 years later compared with those who used saunas only once a week.

At the time, Rita F. Redberg, MD, University of California, San Francisco, wrote in a JAMA Internal Medicine Editor's Note that although the study didn't include mechanistic examination, "clearly time spent in the sauna is time well spent."

Dr Laukkanen noted that after looking at the associations with cardiovascular disease the researchers next wanted to turn their attention to dementia "because together, they often share comorbidities and risk factors."

The original KIHD study was created to examine risk factors for atherosclerotic cardiovascular outcomes in a randomly selected, population-based sample of men from eastern Finland.

For the current analysis, the investigators examined a cohort of 2315 of the participants who reported their sauna use. All of the men were aged 42 to 60 years at baseline (mean age, 53.1 years).

Traditional Finnish saunas were used by all of the study participants. These versions have dry air and a recommended temperature of 80 to 100°C. And humidity "is temporarily increased by throwing water on the hot rocks of [the] sauna heater."

The men were split into 3 subgroups based on weekly sauna use averages: once a week (n = 601), 2 to 3 times a week (n = 1513), and 4 to 5 time a week (n = 200).

The mean follow-up time was 20.7 years. For each group, from the least sauna use to the most, the percentages with a dementia diagnosis were 10%, 9%, and 4%, respectively; 6%, 6%, and 3% had an AD diagnosis.

Generalizable Results?

After adjustment for a multitude of factors, including age, body mass index, smoking status, alcohol consumption, and having had a prior myocardial infarction, the hazard ratio (HR) for dementia was 0.34 for the 4 to 7 times per week sauna bathers vs the once a week bathers (95% confidence interval [CI], 0.16 - 0.71; P = .004).

The HR for AD for the same comparison was 0.35 (95% CI, 0.14 - 0.90; P = .03).

There were no significant associations with dementia or AD for the 2 to 3 times per week vs once per week sauna bathers.

Overall, the findings show "a strong inverse association between frequency of sauna bathing and the risk of dementia and [AD], which was independent of known risk factors," write the investigators.

They note that recent evidence has suggested that inflammation and oxidative stress may contribute to the pathogenesis of dementia.

"Our results are therefore biologically plausible as regular sauna bathing is associated with improved vascular endothelial function, which also leads to reduced inflammation," the researchers write.

"Additionally, sauna bathing may be beneficial in the reduction of high systemic blood pressure and elevated pulse pressure, which are also well-known risk factors for dementia."

Dr Laukkanen added that he thinks the results are generalizable "to other populations in the northern part of the world: in northern countries in Europe and in North America, where they have cold weather. But I don't know how generalizable it would be in warmer countries."

He reported that the researchers are planning future studies that will assess these associations in women and assess other physiologic changes with sauna use.

The study was funded by the Finnish Foundation for Cardiovascular Research. Dr Laukkanen and the other study authors have disclosed no relevant financial relationships.

Age Ageing. Published online December 7, 2016.

    
相關報導
腦中的鐵質或許可以預測阿茲海默氏症的病程
2017/2/7 下午 05:58:31
前列腺癌使用ADT治療會增加失智風險嗎?
2016/11/2 下午 04:54:59
抗精神病藥增加阿茲海默氏症患者的肺炎風險
2016/9/13 上午 11:21:52

上一頁
   1   2   3   4   5   6   7   8   9   10  




回上一頁