鋅可以提高低出生體重嬰兒的存活率

降低68%感染性疾病的死亡率

  2002年1月8日報導──據《Pediatric》雜誌12月一期中報導的一項研究顯示,對低出生體重嬰兒給予鋅的補充可以提高他們的存活率。此研究為延續以往的研究發現,低出生體重兒臍帶血中鋅的濃度偏低,及鋅缺乏兒童與免疫力降低和感染性疾病的致病率升高有關。

  美國約翰霍普金斯大學的Sunil Sazawal博士,和他的同事們寫道:「對低出生體重兒鋅的補充可以降低感染性疾病的死亡率。」

  在這次隨機、雙盲的對照實驗中,共有1,154名低出生體重兒接受以下一種治療:核黃素;核黃素加鋅;核黃素、鈣、磷、葉酸和鐵;或核黃素、鋅、鈣、磷、葉酸和鐵。從出生30天到284天,每天固定接受5cc的糖漿劑量。

  鋅的補充能降低86%死亡率,雖然補充鈣、磷、葉酸和鐵的兒童死亡率也下降了12%,但是不具統計學上的差異。

  作者寫道:「提高鋅的濃度和降低兒童死亡率的措施,將會對開發中國家兒童的存活率有重要的影響。」

  

Zinc Improves Survival in Low-Birth-Weight Infants

Cuts Infectious Disease Mortality by 68%

By Laurie Barclay, MD
WebMD Medical News

Reviewed by Charlotte E. Grayson, MD

Jan. 8, 2002 -- Zinc supplementation in low-birth-weight infants improves survival, according to a study reported in the December issue of Pediatrics. This research extends previous findings of low zinc concentrations in cord blood of low-birth-weight infants, as well as the associations between children with zinc deficiency and reduced immunocompetence and increased infectious disease morbidity.

"Zinc supplementation in small-for-gestational-age infants can result in a substantial reduction in infectious disease mortality," write Sunil Sazawal, PhD, and colleagues from Johns Hopkins University.

In this randomized, double-blind, controlled trial, 1,154 full-term, small-for-gestational-age infants received one of the following: riboflavin; riboflavin and zinc (5 mg as sulfate); riboflavin, calcium, phosphorus, folate, and iron; or riboflavin, zinc, calcium, phosphorus, folate, and iron. Each child received a fixed dosage of 5 mL in syrup daily from 30 to 284 days of age.

Zinc supplementation was associated with a 68% reduction in mortality. Although there was a 12% reduction in mortality with calcium, phosphorus, folate, and iron supplementation, this was not statistically significant.

"The potential of interventions to improve zinc status and reduce infant mortality has important implications for child survival in developing countries," the authors write.

© 2002 WebMD Corporation. All rights reserved.

    
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