January 4, 2008 — 新的研究結果顯示,經前症候群(PMS)女性的自律神經系統(ANS)活性顯著下降,且症狀嚴重的可能會使該關鍵調節系統功能永久低下。
  這項由Tamaki Matsumoto博士領導進行的研究,發表於12月20日的生物精神社會醫學期刊上。

PMS Linked to Decreased Autono

By Caroline Cassels
Medscape Medical News

January 4, 2008 — New research shows that women with premenstrual syndrome (PMS) have significantly decreased autonomic nervous system (ANS) activity and that those with the most severe symptoms might have permanent depression of this key regulatory system.

Conducted by investigators at the International Buddhist University in Osaka, Japan, the study shows that women with PMS have significantly decreased ANS activity in the late-luteal phase of their menstrual cycle, compared with the follicular phase.

The results also suggest that among women with premenstrual dysphoric disorder (PMDD), who have the most severe symptoms, this decreased ANS activity is permanent regardless of menstrual-cycle phase.

Although the underlying pathophysiologic mechanisms remain unclear, the current study suggests that altered functioning of the ANS in the late-luteal phase is associated with diverse psychosomatic and behavioral symptoms appearing premenstrually.

"In addition, when the symptoms become more severe, as seen in women with PMDD, the sympathovagal function might be more depressed, regardless of the menstrual cycle," the authors write.

The study, which was led by Tamaki Matsumoto, PhD, was published online December 20 in BioPsychoSocial Medicine.

According to the paper, previous research has shown that autonomic function is altered in psychosomatic symptoms such as depression, anxiety, and chronic fatigue.

However, despite the fact that up to 90% of women of childbearing age experience at least some degree of PMS and 3% to 5% are estimated to have PMDD, the researchers note there is little information regarding the potential association of PMS and ANS activity.

To investigate whether ANS activity is altered during the menstrual cycle of women with different degrees of premenstrual symptomatology, the researchers recruited 62 women in their 20s, 30s, and 40s with regular menstrual cycles.

All subjects were examined during the follicular phase and again during the late-luteal phase of their cycle.

During these examinations, subjects underwent urine sampling to verify hormone levels, and their physical emotional and behavioral symptoms were assessed using the Menstrual Distress Questionnaire. On the basis of this testing, subjects were classified into 3 groups: PMS, control, and PMDD.

ANS activity was assessed using heart-rate variability power spectral analysis, which the researchers note has been shown in previous studies to provide comprehensive noninvasive assessment of the parasympathetic components of the ANS.

There were no differences in any of the heart-rate-variability parameters among women with no PMS who made up the control group. In contrast, women who experienced PMS symptoms in the late-luteal phase experienced an overall decrease in autonomic and parasympathetic nerve activity; those in the PMDD group experienced marked decreases in ANS activity, regardless of menstrual cycle phase.

The investigators note that further research is "needed to confirm an etiological association of premenstrual symptomatology with the complex web of bio-psycho-social factors around the menstrual cyclicity of sympathovagal function."

The authors have disclosed no relevant financial relationships.

Biopsychosoc Med. 2007; 20;1(1):24. Abstract

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